chances of chemical pregnancy with pgs normal embryo

END MENT And the fact that the embryo's are at least starting to implant is confusing me in relation to my lining - Does that mean that my thinner lining is OK? We have one (and only one) 4bb PGS normal embryo. An embryo with more or fewer than 23 chromosome pairs may be at increased risk of miscarriage or certain genetic disorders. Youre right! My doctor really only wants me to transfer one embryo, my husband and I want to do 2. Hoping to hear from them soon . Both Chemical pregnancies my lining was under 7. Does it still matter? Objective: To determine whether undetected aneuploidy contributes to pregnancy loss after transfer of euploid embryos that have undergone array comparative genomic hybridization (aCGH). Best of luck to you with your upcoming FET, my thoughts and prayers are with you! The ERA was about $800 and it took about 2 weeks to get the results. MENTS my 3rd FET was a success end MENTS. Genetic testing was normal. I actually didnt have embryos to bring with me when we switched. My first FET was a day 6 5AA euploid embryo. She said she is willing to do so but against her medical advice. Maybe the wash too? Go figure, right?! PGS Normal FET Results in Chemical Pregnancy *with* autoimmune protocol, Need some Love!!! thank you so much! I know it only takes one good embryo to be successful and I understand the odds of having a good enough embryo to send for testing and having that testing turn out normal is very small. Do you think it's worth it as last time I had a medicated cycle and it was a . Can any further conclusion be made based on number of normal pgs results ? This was our first trial. PGS Testing Risks - CNY Fertility , Ive done embryo glue every transfer but no luck unfortunately :(. Success stories with 2 PGS normal embryos? - HealthUnlocked I know Ive had issues with my lining but for each of the chemical pregnancies we were able to get my lining to at least 8mm with a mixture of puregon and cetrotide injections, instead of estrace, as well as PRPs. But I dont think we can compare those two sets of numbers to really tell if PGS is increasing our success rates per age group. I did not do an ERA although I know a lot of people who have and have gathered helpful info from it. They also provided information for the chance of getting no euploids per cycle: So as age increases, the chances of getting a euploid embryo drop. He earned his MSc in 2012 for his research on inflammation and lung cancerand started Remembryo in 2018 to help people understand the evidence behind common IVF topics. Any advice is greatly appreciated. Hi, sorry about your 1st FET chemical. Women who have three chromosomally-normal embryos as a result of In Vitro Fertilization (IVF) have a 94.9% chance of achieving pregnancy, research conducted by Reproductive Medicine Associates (RMA) and presented at the annual meeting of the American Society for Reproductive Medicine (ASRM) shows. They biopsied those 2 embryos and send off the cells for PGS testing. MENTS our next transfer was successful and I'm coming up on 12 weeks. I had biopsies after a polyp removal which showed residual B cells (even after 3 rounds of antibiotics), my RE didn't think much of it. Currently 8 weeks. PGT-M and PGT-A Genetic Screening Before IVF - Verywell Family Will be put on lovenox this round as well. Thanks in advance! Your story does give me hope and I wish my little one is as strong as yours! Another small study found no difference in survival or live birth rates with rebiopsied embryos (Cimadomo et al. Pre-implantation Genetic Testing for Aneuploidies (also known as PGT-A, or historically known as PGS or CCS) is a diagnostic tool to tell your fertility doctor which embryos are likely to be chromosomally-normal and thus which to transfer. frustration and tears were worth it. The FET process can take a few tries even with a PGS tested embryo. It was an incredibly long and intense process but looking back I did not have time on my side for my eggs so it was the right decision for us. I pay completely out of pocket for everything so the added expense was not something I wasnt looking forward to, but Im happy I went through with it. Your post will be hidden and deleted by moderators. This is my second failure of a PGS tested embryo, and the first on this immune suppressing protocol. Aww happy your second round worked! Chances for getting a euploid embryo A recent 2019 study looked at 130,000 biopsies by NGS tested (this is the current testing method): Donor eggs: 63.1% euploid <35 years: 59.5% euploid 35-37 years: 50.3% euploid 38-40 years: 38.3% euploid 41-42 years: 26.8% euploid 43-44 years: 24% euploid Did your doctor have your SO go through the rounds of antibiotics as well? I did switch clinics in the middle and felt that my new clinic cared more about me and was more aggressive in testing for other things and adding new medications to my cycles. Generally, Day 5 embryos perform better than Day 7 embryos. This may be used to avoid a gender-linked genetic disorder or (more rarely) for family balancing. While I know my struggles are not unique I still feel so alone in this journey. Consult with your doctor before making any treatment changes. MENTS my FET following that one was successful and I am now 28 weeks pregnant END MENTS .This whole IVF journey takes so much out of you and I truly feel your pain but please keep trying. I have to say that I'm not 100% sure I needed any of the extra things we did- but I wanted to try whatever I could and these things couldn't hurt. How does PGS improve IVF success rates? - Infertility Aide We had two from #4 cycle- one normal boy embryo and another that they said they didn't have enough material to test. On September 20th, we did my first IVF cycle. You may want to ask/consider this before moving on for more data before trying with another precious embryo. There was also no difference with Day 7, although the sample size was very small. yes! How does anyone not go completely crazy through this whole process???? He suggested an endometrial biopsy instead. How IVF with PGS is Changing the Fertility Game for Women over Age 35 I just wanted to know if anyone had a similar experience and if you can share the things you did differently with your second transfer and had success? A recent 2019 study looked at 130,000 biopsies by NGS tested (this is the current testing method): Demko et al. You have to do whatever you feel comfortable with and its so unfortunate that money plays a huge role in these decisions. - 2 Day 5's transferred ended in a chemical pregnancy; 1 perfect Day 6 blast ended up making me a mom. Additionally, my RE says sometimes they will recommend these medications even if you test negative but have recurrent pgs transfer failures with no other explanations (you might want to search autoimmune immune protocol on these boards). Best of luck on your next FET! So in your case it might be different since yours are chemical pregnancies but still worth asking I think :) Also someone above mentioned the endometrial biopsy which would also probably be a good idea. - continued the same above protocol with the only change was that once I got my first positive beta (63) they had me increase the progesterone suppository to three times a day. Live birth rate differences are inconsistent and therefore inconclusive. These studies were particularly small so drawing conclusions isnt really possible yet. All the comments on here seem pretty helpful already. I paid a fortune for those sessions (I dont have insurance). Im assuming you had no issues shipping yours? If you did PGS after multiple miscarriages and failed attempts how many did you transfer? Im currently 17 weeks from another FET. So all the aneuploid embryos that were transferred either didnt implant, or miscarried. In contrast to mosaic embryos that are a mix of euploid and aneuploid cells, aneuploid embryos are completely aneuploid and all the cells are abnormal. Don't lose hope! Praying you did and thank you for the advice! It kind of makes me wonder what they get out of their alternative recommendations. I actually didn't do acupuncture the second cycle, but I was in great shape. They also did a subgroup analysis using this data for age groups <35 and >35. I just officially confirmed another Chemical pregnancy for me. Embryos with the right number of chromosomes are called euploid and may have a higher chance of making a pregnancy, although the evidence for this is controversial. I had been on birth control since I was 18 and had no idea what to expect when I came off it. Besides that, there are no gaurantees of both sticking. Success is still very possible, IVF treatments are often a trial and error situation as my doctor put it once. That makes me feel better about transferring to another clinic, which Im thinking might be the best bet at this point! Well also look at the chances of getting a euploid based on age, the impact of embryo grade and the day it was frozen (Day 5, 6 or 7), and how rebiopsies or thaw and biopsies fare for success rates. The only thing different medication wise was that I took a baby aspirin once daily starting the day of transfer the second time. In this case the clinic will need to: So the embryo would have to go through multiple rounds of freezing/thawing/biopsy, and this might have an impact on its potential. I remember you from another post I made about only having 2 eggs fertilized you were so kind to share your story. We did do some things differently, however my RE did these things more to appease me because he knew how frustrated I was than because he thought they were medically necessary. Did you carry to full term? And since then Ive had medical issues that havent allowed me to try again until last month. Hi lovely people , as per your recommendations I went for another egg retrieval and did pgs testing on 3 embryos out of which 2 came back normal. (2018)looked at about 650 transfers ofPGS tested euploidembryos (based onSNPtechnology) across various ages: So it looks like the success rates hover around 60-70% in most cases, with women >42 having about a 50% live birth rate per transfer. However, the two transfers we did werent PGS tested. We have one day 7/Euploid Blast 5BB remaining on ice. I would Love and Need your opinions on this. It was a chemical pregnancy. Your post will be hidden and deleted by moderators. https://www.remembryo.com/embryo-news-pgs-testing-doesnt-improve-success-in-good-prognosis-patients/. Talk about adjusting meds? One clinic determined IVF with PGS success rates to have a 10% higher pregnancy rate. This is important because miscarriage rates with advancing female age. I find the live birth rates by transfer versus by retrieval data very interesting. Of course the quality of the embryo is everything but there is significantly more uterine prep with a frozen transfer and I think it helped. And Im so sorry about your first FET. So, all is well! Other studies seem to suggest a 8-11% chance of miscarriage with a euploid transfer. Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. We have our lining check on Friday. No clinic ended up quoting more than 60-70% . I had a chemical pregnancy with my first FET. I was more relaxed overall at the second transfer, and maybe that helped. You got this! I suspected that my Hashimotos had something to do with the chemicals so we figured we will do IVF#4 and PGS test the embryos. I go for my next Beta tomorrow. The results come back as euploid (meaning theres 46 chromosomes), aneuploid (meaning theres a number of chromosomes besides 46) or mosaic (meaning theres a mix of euploid and aneuploid cells). What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. Create an account or log in to participate. This was something that almost all of our embryos had problems with (a high drop off rate of embryos growing in the lab and all were always low rated if they made it to blastocyst stage). With the retrieval statistics, we can include all cycles (like the ones that ended with no blasts to transfer or only abnormal embryos that werent transferred) and that lowers the success rates quite a bit. PGS testing (aka PGT-A) is a technique to help choose the best embryo for an embryo transfer. All that to say, it's likely that there actually was something wrong with that embryo - but it's worthwhile to leave no stone unturned before trying again. The psychologist who ran the group, who also happened to be an RE at my fertility clinic, explained that sometimes you have a seemingly perfect embryo, perfect uterine lining, and the FET just fails. Trying naturally, assisted, etc. Group Black's collective includes Essence, The Shade Room and Naturally Curly. By 40 theres about a 1 in 4 chance of not getting a euploid and by 43 this doubles to half. I have one more embryo remaining. Last January we found out we were pregnant but had a miscarriage at 7 weeks. also did you have to do another stim cycle? Unfortunately my 2nd retrieval wasnt as positive as yours - I didnt have any make it to blast So Im struggling with my next steps (as Im older) and whether a 3rd retrieval makes sense given the odds. Advice please: has anyone here who ha - Fertility Network UK Check here for the full. I just looked briefly online and saw mixed reviews about embryos being damaged when shipped. Which was Claritin, pepcid, and baby aspirin. About 7 months later I transferred a day 7. Viotti et al. No additional testing has been offered after 3 chemicals and one failed implantation on PGS normal embryos - he just tries to push me onto surrogacy each time saying sometimes thats the only option. My first fresh transfer ended in miscarriage due to low progesterone, I was on supplements but not enough. After I had my 3rd, my doctor and the IVF nurses all pushed for an ERA saying that even though Ive had prior success, that may have just been luck and my optimal window might be different than what I was doing. Can you tell me the success rate? , ERA was a game changer for me! I also tested positive for anti-thyroid antibodies. I feel so lucky that I found this community. Poor quality embryos are they worth PGS testing? Patient(s): Cases included 38 patients who underwent frozen euploid ET as determined by aCGH, resulting in miscarriage. My second was ectopic, my third was a failure and Im about 7.5 weeks pregnant from my 4th (). We transferred our only day 6/PGS tested Euploid embryo on December 10,2020. My doctor is recommending a Receptiva test to uncover any other reasons why the pregnancies won't last. thank you for sharing your success story! Thats a great suggestion, I will definitely ask my dr about doing an ERA. Im sure that data exists especially since thats how things used to be done back in the day. Started with 14 eggs, 7 fertilized and only 1 made it to blast and ended up being abnormal. I went into my second egg retrieval and got less eggs than the first time around. Ill have to ask my RE for options. Reply Share React operationpepper Dec 22, 2015 3:42 PM Would love to hear if it was successful - fingers crossed . A doctor can confirm it by testing blood for human chorionic gonadotropin (hCG . (2018)looked ateuploidembryos (aCGH/SNP) in women <35: Irani et al. Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. PGT-A (formerly PGS testing) is a technique that determines the number of chromosomes in the cells of an embryo. The chances of having a positive outcome with PGS testing and IVF depend on the number of the produced embryos that have a positive result in the test. Weve spent almost 45K on this process and we are with a reputable clinic affiliated with CCRM so I am confident they know what they are doing but you cant also help but wonder is there more that can be done Im waiting to hear from the team to see if shes given some more thoughts. Please specify a reason for deleting this reply from the community. That said, Im still glad that I pursued additional testing and second opinions just in case. It was a chemical pregnancy. While a PGS normal embryo means the chromosomes are normal, there is more to a baby than just chromosomes and sometimes it just doesnt work. With a PGS tested embryo this time. In a small study,Bradley et al. I know PGS tested embryos can still have issues but its been 4 transfers now with no success so Im wondering if theres a deeper issue. Last year I got pregnant from an IUI and miscarried at 8 weeks. I honestly wish I had but thats all hindsight now knowing what I knew. Recurrent Chemical Pregnancy - PGS embryo (and Donor egg ) Advice needed. Weve discussed euploid embryos, mosaic embryos, so what about aneuploid embryos? I am hoping number 5 is it. Ive seen conflicting studies with some (irani 2017) saying poor quality euploid has just 25% LBR but some more recent studies (2021) that suggest that morphology matters more under 30 (which Im not Im 42 but was 37/8 at retrieval). What are the miscarriage rates with PGT embryos? : r/IVF - Reddit This was my only PGS normal embryo so I have to re-do that as well.. Dear RLM11, so sorry for your losses, I know how devastating it is! This educational content is not medical or diagnostic advice. I know how devastating loss can be but theres always, always hope. I completely understand struggling about whether to do the 3rd retrieval, it is a lot to go through all over again. I am currently 6w5d pregnant, which is the farthest Ive been. I am not naive I know bad things can happen. Note: I'm also doing a pregnancy loss blood panel to investigate clotting, and am looking into autoimmune causes as well. Autoimmune Testing? PGT-A can also identify the gender of an embryo. My TSH was marginally high and I started synthroid. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. How Does PGS Testing Work? - Success Rate & Risks - Coastal Fertility I am so frustrated, disappointed, hurt, sad and angry right now. She says that with PGS tested embryos my rate to achieve pregnancy is 70% and a twin pregnancy is at 50%. (I had these done at a private lab since my nurse wouldn't let me come in early) My last donor embryo cycle was also a chemical pregnancy but no PGS was done. How did your pregnancy turn out? More info in my profile about my testing and treatment, and Im open to answering any questions. Please specify a reason for deleting this reply from the community. Best of luck to you. Hi all, 2 - IVF both miscarriages around 6 weeks Normal Embryo Success Rate: RMA Research Study Not exactly! Women above 35 seem to benefit the most with PGS . Endomitritis is basically an inflammation in the uterus that makes it inhospitable for an embryo to implant or grow. Disclaimer: Any studies presented here may be contradicted by other studies. So crazy that its what finally worked. I am 42. For more up-to-date information on this topic check out my other posts that are tagged withPGS (PGT-A) success rates. I'm curious if this might have something to do with it. Apparently some women have different windows of, Implantation and I found out this week that I need 24 hours additional progesterone which could be the reason for the other chemicals. Im sorry for your loss My first was also a frozen transfer and I agree, there is more prep involved. Some of the issues with the studies included in the meta-analysis were brought up: Future studies should focus on single embryo transfers, and in women >35, to see if PGT-A truly has a reduction in miscarriage rates for this age group. Chemical pregnancies occur so early that many people who miscarry don't realize it. I can totally see not doing it though. TTC 3 years thanks so much! He was surprised my doctor was doing a Receptiva test naturally, without medication, since the idea is to simulate the same environment of a transfer, and was also surprised that my doctor had done a 5-day-post-retrieval-transfer in the first place. After 10 days, they came back and said that it was low and that i should mentally prepare myself for a chemical pregnancy. Women over 35 were not shown to have increased pregnancy rates from PGT unless they made many embryos that needed evaluation. However, that information will still be included in details such as numbers of replies. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. We strive to provide you with a high quality community experience. You said that The per retrieval statistic helps to see the chances before PGS testing. But it almost seems like there should be another set of statistics for better putting success rates into perspective. For these groups, about 50% of biopsies had noeuploidembryos. amazing, that gives me hope :) thanks so much! 5AB euploid embryo. My RE had said shes usually very cautious when it comes to sending embryos out for PGS testing only because the process can sometimes compromise the embryo itself. Whitney et al. I'm in a similar situation so will ask my RE about all of this! Mosaics are embryos that have a mix of euploid and aneuploid cells. Some of the reasons quoted weren't even about the patient: it could have been damaged during the biopsy or thaw process in the lab, the transfer process could have been off, there's a margin of error with the testing itself, pgs doesn't tell us everything about an embryo, etc. Comprehensive Chromosome Screening (CCS) is one technique of PGT-A that can identify whether an embryo is XX (female) or XY (male). Wishing you lots of luck. However we now understand that the chromosomes are only part of the issue. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. My first FET with my only normal embryo was successful but ended at 7.5 weeks with a MMC The devastation was unreal. Or is that the reason they don't continue to progress? I am terrified he wont implant. Because all the women who didnt have embryos to transfer are now included and lower the overall success for that age group. I also want to add low dose prednisone and lovenox - I have heard from so many of you that even IF no autoimmune issues are found that this combo helps. If I had transferred two without PGS, there would have been a significant chance that both would have been abnormal. However, theirsample sizewas small. Thanks for commenting! my first 2 cycles were artificial but my last 2 were natural and unfortunately no luck :( Hopefully we can get somewhere with the ERA. (2014)found no difference inongoing pregnancieswith Day 5 or 6 euploids (about 50%). Good luck and wishing baby dust your way soon! PGS or Transfer 2 embryos? - Infertility - Inspire
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